APPENDIX - Derivation of the Method

APPENDIX2 - Diagram of Receptor Activation



A diagram showing how the acid-base, two-state model would produce receptor activation:


Where D is the binding ligand and RH and RL are the states of the receptor corresponding to the high and low affinity states respectively. G is the G protein and E is the enzyme within the cell that is activated by the alpha subunit of the G protein. DeltaRH represents the net shift produced by the relative unequal binding of D to RH and RL, which produces the receptor response (see and click on the picture to see the derivation of this model).


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